Structural white matter and functional connectivity alterations in patients with shoulder apprehension

Zanchi, Davide; Cunningham, Gregory; Laedermann, Alexandre; Ozturk, Mehmet; Hoffmeyer, Pierre; Haller, Sven

doi:10.1038/srep42327

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Structural white matter and functional connectivity alterations in patients with shoulder apprehension
Authors		Zanchi, Davide Cunningham, Gregory Laedermann, Alexandre Ozturk, Mehmet Hoffmeyer, Pierre Haller, Sven
Published in		Scientific reports. 2017, vol. 7, 42327
Abstract		Previous functional magnetic resonance imaging (fMRI) findings indicate that shoulder apprehension is more complex than a pure mechanical problem of the shoulder, showing a direct modification in functional brain networks associated with motor inhibition and emotional regulation. The current study extends these findings by investigating further structural alterations in patients with shoulder apprehension compared to controls. 14 aged patients with shoulder apprehension (27.3 ± 2.0 years) and 10 matched healthy controls (29.6 ± 1.3 years) underwent clinical and fMRI examination including fMRI and diffusion tensor imaging (DTI). Tract-based spatial statistics procedure was used to analyze white matter (WM) alterations. Functional images were analyzed investigating resting state network connectivity. DTI results were correlated with different shoulder clinical scores and functional connectivity networks. Fractional anisotropy (FA), representing white matter integrity, is increased in the left internal capsule and partially in the thalamus in patients compared to controls. Moreover, FA correlates negatively with simple shoulder test (SST) scores (p < .05) and positively with a functional connectivity network qualitatively replicating previous results (p < .01). This study extends previous findings, showing that in addition to functional changes, structural white matter changes are also present in patients with shoulder apprehension.
Identifiers		DOI: 10.1038/srep42327 PMID: 28176877
Full text		Article (Published version) (494 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949) Thérapie cellulaire et troubles musculo-squelettiques (960)
Citation (ISO format)		ZANCHI, Davide et al. Structural white matter and functional connectivity alterations in patients with shoulder apprehension. In: Scientific reports, 2017, vol. 7, p. 42327. doi: 10.1038/srep42327 https://archive-ouverte.unige.ch/unige:93744