UNIGE document Scientific Article
previous document  unige:93719  next document
add to browser collection
Title

Impact of graft implantation order on graft survival in simultaneous pancreas-kidney transplantation

Authors
Published in Transplant International. 2016, vol. 29, no. 5, p. 627-35
Abstract The optimal order of revascularization for pancreas and kidney grafts in simultaneous pancreas-kidney transplantation has not been established. In this study, we investigate the influence of graft implantation order on graft survival in SPK. 12 700 transplantations from the Scientific Registry of Transplant Recipients were analyzed retrospectively. Graft implantation order was determined based on the reported ischemia times of pancreas and kidney grafts. Pancreas and kidney graft survivals were analyzed depending on graft implantation order at 3 months and 5 years using Kaplan-Meier plots. Significance was tested with log-rank test and Cox regression model. In 8454 transplantations, the pancreas was implanted first (PBK), and in 4246 transplantations, the kidney was implanted first (KBP). The proportion of lost pancreas grafts at 3 months was significantly lower in PBK (9.4% vs. 10.8%, P = 0.011). Increasing time lag (>2 h) between kidney and pancreas graft implantation in KBP accentuated the detrimental impact on pancreas graft survival (12.5% graft loss at 3 months, P = 0.001). Technical failure rates were reduced in PBK (5.6 vs. 6.9%, P = 0.005). Graft implantation order had no impact on kidney graft survival. In summary, although observed differences are small, pancreas graft implantation first increases short-term pancreas graft survival and reduces rates of technical failure.
Keywords Simultaneous pancreas-kidney transplantationgraft implantation ordergraft survivalregistry study
Identifiers
PMID: 26987785
Full text
Article (Published version) (370 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie viscérale (104)
Transplantation et hépatologie (905)
Citation
(ISO format)
NICLAUSS, Nadja et al. Impact of graft implantation order on graft survival in simultaneous pancreas-kidney transplantation. In: Transplant International, 2016, vol. 29, n° 5, p. 627-35. https://archive-ouverte.unige.ch/unige:93719

15 hits

0 download

Update

Deposited on : 2017-04-21

Export document
Format :
Citation style :