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Title

Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications

Authors
Schuurman, Henk-Jan
Wandrey, Christine
Gerber-Lemaire, Sandrine
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Published in Methods in Molecular Biology. 2017, vol. 1506, p. 259-271
Abstract Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications.Here, we describe the protocol for microencapsulation of hepatocytes and mesenchymal stem cells within hybrid poly(ethylene glycol)-alginate hydrogels.
Keywords AlginateCapsuleCirrhosisEncapsulationFibrosisHepatitisHepatocyteHydrogelsLiver failureMesenchymal stem cellsMicrobeadsMicrospheres
Identifiers
PMID: 27830559
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Structures
Research groups Chirurgie viscérale (104)
Transplantation et hépatologie (905)
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MEIER, Raphaël et al. Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications. In: Methods in Molecular Biology, 2017, vol. 1506, p. 259-271. https://archive-ouverte.unige.ch/unige:93715

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Deposited on : 2017-04-21

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