Scientific article

Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications

Published inMethods in molecular biology, vol. 1506, p. 259-271
Publication date2017

Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications.Here, we describe the protocol for microencapsulation of hepatocytes and mesenchymal stem cells within hybrid poly(ethylene glycol)-alginate hydrogels.

  • Alginate
  • Capsule
  • Cirrhosis
  • Encapsulation
  • Fibrosis
  • Hepatitis
  • Hepatocyte
  • Hydrogels
  • Liver failure
  • Mesenchymal stem cells
  • Microbeads
  • Microspheres
Citation (ISO format)
MEIER, Raphaël et al. Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications. In: Methods in molecular biology, 2017, vol. 1506, p. 259–271. doi: 10.1007/978-1-4939-6506-9_18
Main files (1)
Article (Published version)
ISSN of the journal1064-3745

Technical informations

Creation03/02/2017 3:14:00 PM
First validation03/02/2017 3:14:00 PM
Update time03/15/2023 1:36:41 AM
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