UNIGE document Scientific Article
previous document  unige:93715  next document
add to browser collection

Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications

Schuurman, Henk-Jan
Wandrey, Christine
Gerber-Lemaire, Sandrine
show hidden authors show all authors [1 - 9]
Published in Methods in molecular biology. 2017, vol. 1506, p. 259-271
Abstract Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications.Here, we describe the protocol for microencapsulation of hepatocytes and mesenchymal stem cells within hybrid poly(ethylene glycol)-alginate hydrogels.
Keywords AlginateCapsuleCirrhosisEncapsulationFibrosisHepatitisHepatocyteHydrogelsLiver failureMesenchymal stem cellsMicrobeadsMicrospheres
PMID: 27830559
Full text
Article (Published version) (408 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Transplantation et hépatologie (905)
(ISO format)
MEIER, Raphaël et al. Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications. In: Methods in molecular biology, 2017, vol. 1506, p. 259-271. doi: 10.1007/978-1-4939-6506-9_18 https://archive-ouverte.unige.ch/unige:93715

525 hits

0 download


Deposited on : 2017-04-21

Export document
Format :
Citation style :