UNIGE document Scientific Article
previous document  unige:93704  next document
add to browser collection

Intraportal islet transplantation: the impact of the liver microenvironment

Published in Transplant international. 2017, vol. 30, no. 3, p. 227-238
Abstract The portal vein remains the preferred site for pancreatic islet transplantation due to its easy access and low morbidity. However, despite great progress in isolation and transplantation protocols over the past few years, it is still associated with the early loss of some 50-70% of transplanted islets. The complex liver microenvironment itself presumably plays an important role in this loss. The present review focuses on the specifics of the liver microenvironment, notably the localized hepatic ischemia/reperfusion injury following transplantation, the low oxygenation of the portal vein, the instant blood-mediated inflammatory reaction, the endogenous liver immune system, and the gut-liver axis, and how they can each have an impact on the transplanted islets. It identifies the potential, or already applied, clinical interventions for improving intraportal islet survival, and pinpoints those promising areas still lacking preclinical research. Future interventions on clinical intraportal islet transplantation need to take into account the global context of the liver microenvironment, with multi-point interventions being most likely to improve early islet survival and engraftment.
Keywords gut-liver axisinstant blood-mediated inflammatory reactionischemia/reperfusionislet transplantationliver microenvironment
PMID: 28109023
Full text
Article (Published version) (587 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups La transplantation d'îlots de Langerhans (623)
Transplantation et hépatologie (905)
(ISO format)
DELAUNE, Vaihere et al. Intraportal islet transplantation: the impact of the liver microenvironment. In: Transplant international, 2017, vol. 30, n° 3, p. 227-238. doi: 10.1111/tri.12919 https://archive-ouverte.unige.ch/unige:93704

417 hits



Deposited on : 2017-04-21

Export document
Format :
Citation style :