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Acute bilateral mydriasis associated with anti-GQ1b antibody

Aqallal, A
Lagrange, E
Besson, G
Caudie, C
Published in Journal of Clinical Neuroscience. 2010, vol. 17, no. 4, p. 514-515
Abstract Miller Fisher syndrome (MFS) is an autoimmune neuropathy characterized by external ophthalmoplegia, ataxia and areflexia. Mydriasis is present in 35% of typical MFS. We report five patients with acute bilateral mydriasis, either isolated or associated with external ophthalmoplegia for which the presumed diagnosis of "atypical MFS" was confirmed by the positivity of anti-GQ1b antibodies. Acute bilateral mydriasis raises important differential diagnoses in clinical practice. This report demonstrates that acute mydriasis can be autoimmune mediated and that anti-GQ1b antibodies are useful to confirm the diagnosis in unexplained cases.
Keywords AdolescentAdultAutoantibodies/bloodAutoantigens/immunologyFemaleGangliosides/immunologyHumansMaleMiddle AgedMiller Fisher Syndrome/blood/complications/immunologyMydriasis/etiologyOphthalmoplegia/etiology
PMID: 20093031
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FLEURY, Vanessa et al. Acute bilateral mydriasis associated with anti-GQ1b antibody. In: Journal of Clinical Neuroscience, 2010, vol. 17, n° 4, p. 514-515. doi: 10.1016/j.jocn.2009.06.030

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Deposited on : 2017-04-20

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