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Alveolar gas composition during maximal and interrupted apnoeas in ambient air and pure oxygen

Fagoni, Nazzareno
Taboni, Anna
Vinetti, Giovanni
Bottarelli, Sara
Published in Respiratory Physiology & Neurobiology. 2017, vol. 235, p. 45-51
Abstract INTRODUCTION: We tested the hypothesis that the alveolar gas composition at the transition between the steady phase II (φ2) and the dynamic phase III (φ3) of the cardiovascular response to apnoea may lay on the physiological breaking point curve (Lin et al., 1974). METHODS: Twelve elite divers performed maximal and φ2-interrupted apnoeas, in air and pure oxygen. We recorded beat-by-beat arterial blood pressure and heart rate; we measured alveolar oxygen and carbon dioxide pressures (PAO2 and PACO2, respectively) before and after apnoeas; we calculated the PACO2 difference between the end and the beginning of apnoeas (ΔPACO2). RESULTS: Cardiovascular responses to apnoea were similar compared to previous studies. PAO2 and PACO2 at the end of φ2-interrupted apnoeas, corresponded to those reported at the physiological breaking point. For maximal apnoeas, PACO2 was less than reported by Lin et al. (1974). ΔPACO2 was higher in oxygen than in air. CONCLUSIONS: The transition between φ2 and φ3 corresponds indeed to the physiological breaking point. We attribute this transition to ΔPACO2, rather than the absolute PACO2 values, both in air and oxygen apnoeas.
Keywords Interrupted apnoeaMaximal apnoeaOxygen apnoeaPACO2Alveolar gasDiaphragmatic contraction
PMID: 27721037
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FAGONI, Nazzareno et al. Alveolar gas composition during maximal and interrupted apnoeas in ambient air and pure oxygen. In: Respiratory Physiology & Neurobiology, 2017, vol. 235, p. 45-51. https://archive-ouverte.unige.ch/unige:93328

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Deposited on : 2017-04-07

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