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Scientific article
English

Cefepime--assessment of its need at a tertiary care center

Contributors

Harbarth, Stéphan Juergen; Pittet, Didier; Gabriel, V.; Garbino, Jorge; Lew, Daniel Pablo

Published in

Journal of clinical pharmacy and therapeutics, vol. 23, no. 1, p. 11-17

Publication date

1998

Abstract

OBJECTIVE: To assess the need and possible indications for a fourth-generation cephalosporin (cefepime). METHOD: A cohort study was carried out over a 17-month period in a 1500-bed Swiss university hospital. RESULTS: In 256 (22.6%) of the 1135 patients followed consecutively by our Infectious Diseases Division, cefepime could have been chosen as an alternative to other broad-spectrum antibiotics, including imipenem/cilastatin (n=94), ciprofloxacine (n=52) and ceftazidime (n=49). Considering the low price-strategy of the pharmaceutical company promoting this drug in Switzerland, there would have been considerable cost savings for the hospital pharmacy if cefepime had been used as first-line treatment in these occasions. Nevertheless, we could not observe any potential advantage of cefepime compared to already introduced broad-spectrum antibiotics, except that cefepime was effective against infections caused by Enterobacter spp. resistant to ceftazidime. CONCLUSION: We conclude that fourth-generation cephalosporins such as cefepime may be introduced into large hospitals only after careful assessment of their potential benefits and that consultation by an Infectious Diseases Division is useful when evaluating the need for new broad-spectrum antibiotics in the hospital setting.

Keywords

  • Adult
  • Aged
  • Anti-Infective Agents/therapeutic use
  • Ceftazidime/ therapeutic use
  • Cephalosporins/ therapeutic use
  • Cilastatin/therapeutic use
  • Ciprofloxacin/therapeutic use
  • Cohort Studies
  • Drug Utilization Review
  • Female
  • Hospitals, University
  • Humans
  • Imipenem/therapeutic use
  • Male
  • Middle Aged
  • Prospective Studies
  • Switzerland
  • Thienamycins/therapeutic use

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

HARBARTH, Stéphan Juergen et al. Cefepime--assessment of its need at a tertiary care center. In: Journal of clinical pharmacy and therapeutics, 1998, vol. 23, n° 1, p. 11–17.

Identifiers

Journal ISSN

0269-4727
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Technical informations

Creation

12/07/2010 14:36:50

First validation

12/07/2010 14:36:50

Update

14/10/2025 06:02:16

Status update

14/03/2023 15:54:21

Last indexation

10/11/2026 13:12:49
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