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Limbal stem-cell therapy and long-term corneal regeneration

Rama, Paolo
Matuska, Stanislav
Paganoni, Giorgio
De Luca, Michele
Pellegrini, Graziella
Published in New England Journal of Medicine. 2010, vol. 363, no. 2, p. 147-55
Abstract Corneal renewal and repair are mediated by stem cells of the limbus, the narrow zone between the cornea and the bulbar conjunctiva. Ocular burns may destroy the limbus, causing limbal stem-cell deficiency. We investigated the long-term clinical results of cell therapy in patients with burn-related corneal destruction associated with limbal stem-cell deficiency, a highly disabling ocular disease.
Keywords AdolescentAdultAgedAged, 80 and overBurns, Chemical/therapyCorneal Diseases/therapyCorneal Transplantation/methodsEndothelium, Corneal/physiologyEye Burns/chemically induced/therapyEye Infections, Bacterial/therapyFemaleHumansKaplan-Meier EstimateLimbus Corneae/cytologyLogistic ModelsMaleMiddle AgedRegenerationStatistics, NonparametricStem Cell Transplantation/methodsTransplantation, AutologousYoung Adult
PMID: 20573916
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RAMA, Paolo et al. Limbal stem-cell therapy and long-term corneal regeneration. In: New England Journal of Medicine, 2010, vol. 363, n° 2, p. 147-55. doi: 10.1056/NEJMoa0905955

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Deposited on : 2017-04-05

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