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Nouveau spectre des troubles cognitifs liés à l'infection par le VIH à l'ère des trithérapies

Du Pasquier, R.
Cavassini, M.
Published in Revue médicale suisse. 2009, vol. 5, no. 201, p. 955-956, 958-961
Abstract Highly active anti-retroviral therapy (HAART) has almost abolished HIV-related mortality and serious opportunistic diseases; among them, AIDS-related dementia. However, minor forms of cognitive dysfunction, have not disappeared, and even increased in frequency. Ageing of HIV+ patients, insufficient penetration of anti-viral drugs into the brain with continuous low-grade viral production and inflammation may play a role. Minor cognitive dysfunction in HIV infection shares some clinical and pathophysiological features with neuro-degenerative diseases, in particular Alzheimers disease. It can thus be postulated that, such in Alzheimer disease, anti-cholinesterase drugs might also be efficacious in AIDS-related minor cognitive dysfunction. This hypothesis has not been tested yet however A clinical trial using ravistigmine is starting this spring in patients with HIV-associated cognitive dysfunction in Geneva and Lausanne.
Keywords AlgorithmsAntiretroviral Therapy, Highly ActiveCognition Disorders/ etiologyHIV Infections/ complications/drug therapyHumans
PMID: 19476058
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DU PASQUIER, R. et al. Nouveau spectre des troubles cognitifs liés à l'infection par le VIH à l'ère des trithérapies. In: Revue médicale suisse, 2009, vol. 5, n° 201, p. 955-956, 958-961. https://archive-ouverte.unige.ch/unige:9311

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Deposited on : 2010-07-12

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