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Scientific article
French

Nouveau spectre des troubles cognitifs liés à l'infection par le VIH à l'ère des trithérapies

Published inRevue médicale suisse, vol. 5, no. 201, p. 955-956,958-961
Publication date2009
Abstract

Highly active anti-retroviral therapy (HAART) has almost abolished HIV-related mortality and serious opportunistic diseases; among them, AIDS-related dementia. However, minor forms of cognitive dysfunction, have not disappeared, and even increased in frequency. Ageing of HIV+ patients, insufficient penetration of anti-viral drugs into the brain with continuous low-grade viral production and inflammation may play a role. Minor cognitive dysfunction in HIV infection shares some clinical and pathophysiological features with neuro-degenerative diseases, in particular Alzheimers disease. It can thus be postulated that, such in Alzheimer disease, anti-cholinesterase drugs might also be efficacious in AIDS-related minor cognitive dysfunction. This hypothesis has not been tested yet however A clinical trial using ravistigmine is starting this spring in patients with HIV-associated cognitive dysfunction in Geneva and Lausanne.

Keywords
  • Algorithms
  • Antiretroviral Therapy, Highly Active
  • Cognition Disorders/ etiology
  • HIV Infections/ complications/drug therapy
  • Humans
Citation (ISO format)
DU PASQUIER, R. et al. Nouveau spectre des troubles cognitifs liés à l’infection par le VIH à l’ère des trithérapies. In: Revue médicale suisse, 2009, vol. 5, n° 201, p. 955–956,958–961.
Identifiers
ISSN of the journal1660-9379
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