UNIGE document Doctoral Thesis
previous document  unige:93095  next document
add to browser collection
Title

Searching for novel players in intraluminal vesicle formation and dynamics

Author
Director
Defense Thèse de doctorat : Univ. Genève, 2017 - Sc. 5059 - 2017/01/31
Abstract The defining morphological characteristic of endosomes is their multivesicular appearance, a product of the formation of intraluminal vesicles (ILVs) that bud from the limiting membrane and into the interior. It is poorly demonstrated how these ILVs arise, and what factors govern their formation and dynamics. In this study, we aimed to develop a robust methodology to monitor ILV formation and back-fusion by analyzing cargo known to traffic via ILVs in the endocytic system and to find novel candidates involved in this process. We have devised and tested a number of novel methods for monitoring the formation and dynamics of ILVs in the endocytic system and characterized the trafficking of ILV-dependent cargo.
Keywords EndocytosisIntraluminal vesiclesMVBInfection,
Identifiers
URN: urn:nbn:ch:unige-930959
Full text
Thesis (79.9 MB) - document accessible for UNIGE members only Limited access to UNIGE (until 2018-09-23)
Structures
Research group Groupe Gruenberg
Citation
(ISO format)
JOHNSON, Shem. Searching for novel players in intraluminal vesicle formation and dynamics. Université de Genève. Thèse, 2017. https://archive-ouverte.unige.ch/unige:93095

63 hits

7 downloads

Update

Deposited on : 2017-04-05

Export document
Format :
Citation style :