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Title

Post-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers

Authors
Kallweit, Ulf
Mathis, Johannes
Jenni, Oskar G
Haba-Rubio, José
Baumann, Christian R
Bassetti, Claudio L A
Published in European Neurology. 2016, vol. 75, no. 3-4, p. 105-8
Abstract Narcolepsy-cataplexy is a sleep-wake disorder and suggested to be immune-mediated, involving genetic and environmental factors. The autoimmune process eventually leads to a loss of hypocretin neurons in the lateral hypothalamus. Epidemiological studies in several countries proved an increased incidence of narcolepsy after H1N1 flu vaccination and infection. This survey in 30 sleep centers in Switzerland led to the identification of 9 H1N1-vaccinated children and adults as newly diagnosed narcolepsy. Clinical features included the abrupt and severe onset of sleepiness, cataplexy and sleep fragmentation.
Identifiers
PMID: 26901055
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Research group Groupe Gasche-Soccal Paola (958)
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KALLWEIT, Ulf et al. Post-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers. In: European Neurology, 2016, vol. 75, n° 3-4, p. 105-8. https://archive-ouverte.unige.ch/unige:92756

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Deposited on : 2017-03-21

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