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Title

The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine

Authors
Kayser, V
Gacel, G
Roques, B P
Published in Brain Research. 1993, vol. 611, no. 2, p. 243-248
Abstract The effect of various doses of the selective delta agonist BUBU (Tyr-D-Ser(O-t-butyl)-Gly-Phe-Leu-Thr(O-t-butyl) on the vocalization threshold to paw pressure were compared in normal and arthritic rats, a suitable clinical model of chronic pain. In both group of rats, the intravenous administration of BUBU (6, 9, 12 mg/kg in normal and 1.5, 3, 6 mg/kg in arthritic rats) led to significant antinociceptive effects. The same dose of BUBU (6 mg/kg i.v.) produced a much more potent antinociceptive effect in arthritic than in normal rats, and a dose as low as 1.5 mg/kg produced a significant analgesic effect in the arthritic animal, whereas at 3 mg/kg BUBU was ineffective in normal rats. The analgesic effects of BUBU (9 mg/kg in normal and 3 mg/kg in arthritic rats) were completely prevented by the selective delta antagonist naltrindole (1 mg/kg i.v. a dose devoid of analgesic potency per se), while they were not affected by the selective mu antagonist naloxone (0.05 mg/kg i.v.). In addition, 3 mg/kg i.v. of BUBU remained effective in morphine tolerant arthritic rats. These results suggest that delta opioid receptor activation can modulate the transmission of cutaneous mechanical nociceptive information in rats, especially in inflammatory pain conditions.
Keywords Analgesics/pharmacologyAnimalsArthritis, Experimental/physiopathologyDrug Administration ScheduleDrug InteractionsEnkephalins/pharmacologyMaleMorphine/administration & dosage/pharmacologyNaloxone/pharmacologyNaltrexone/analogs & derivatives/pharmacologyOligopeptides/pharmacologyPain/physiopathologyRatsRats, Sprague-DawleyReceptors, Opioid, delta/drug effects/physiologyReference ValuesVocalization, Animal
Identifiers
PMID: 8392893
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Article (Published version) (603 Kb) - public document Free access
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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DESMEULES, Jules Alexandre et al. The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine. In: Brain Research, 1993, vol. 611, n° 2, p. 243-248. https://archive-ouverte.unige.ch/unige:92732

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