Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

Waterhouse, R. M.; Kriventseva, E. V.; Meister, Stephan; Xi, Zhiyong; Alvarez, K. S.; Bartholomay, L. C.; Barillas-Mury, Carolina; Bian, Guowu; Blandin, Stephanie; Christensen, B. M.; Dong, Yuemei; Jiang, Haobo; Kanost, M. R.; Koutsos, A. C.; Levashina, E. A.; Li, Jianyong; Ligoxygakis, Petros; Maccallum, R. M.; Mayhew, G. F.; Mendes, Antonio; Michel, Kristin; Osta, M. A.; Paskewitz, Susan; Shin, S. W.; Vlachou, Dina; Wang, Lihui; Wei, Weiqi; Zheng, Liangbiao; Zou, Zhen; Severson, D. W.; Raikhel, A. S.; Kafatos, F. C.; Dimopoulos, George; Zdobnov, Evgeny; Christophides, G. K.

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Title		Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes
Authors		Waterhouse, R. M. Kriventseva, E. V. Meister, Stephan Xi, Zhiyong Alvarez, K. S. Bartholomay, L. C. Barillas-Mury, Carolina Bian, Guowu Blandin, Stephanie Christensen, B. M. Dong, Yuemei Jiang, Haobo Kanost, M. R. Koutsos, A. C. Levashina, E. A. Li, Jianyong Ligoxygakis, Petros Maccallum, R. M. Mayhew, G. F. Mendes, Antonio Michel, Kristin Osta, M. A. Paskewitz, Susan Shin, S. W. Vlachou, Dina Wang, Lihui Wei, Weiqi Zheng, Liangbiao Zou, Zhen Severson, D. W. Raikhel, A. S. Kafatos, F. C. Dimopoulos, George Zdobnov, Evgeny Christophides, G. K. show all authors [1 - 35]
Published in		Science. 2007, vol. 316, no. 5832, p. 1738-1743
Abstract		Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
Keywords		Aedes/ genetics/immunology — Animals — Anopheles/ genetics/immunology — Antimicrobial Cationic Peptides/physiology — Carrier Proteins/genetics/physiology — Drosophila melanogaster/genetics/immunology — Evolution, Molecular — Genes, Insect — Immunity, Innate/ genetics — Insect Proteins/genetics/physiology — Insect Vectors/ genetics/immunology — Malaria/transmission — Melanins/metabolism — Multigene Family — Signal Transduction — Species Specificity
Identifiers		DOI: 10.1126/science.1139862 PMID: 17588928
Full text		Article - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research group		Génomique Evolutionnaire Computationnelle (830)
Citation (ISO format)		WATERHOUSE, R. M. et al. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. In: Science, 2007, vol. 316, n° 5832, p. 1738-1743. https://archive-ouverte.unige.ch/unige:9273