Scientific article
Open access

Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

Published inScience, vol. 316, no. 5832, p. 1738-1743
Publication date2007

Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.

  • Aedes/ genetics/immunology
  • Animals
  • Anopheles/ genetics/immunology
  • Antimicrobial Cationic Peptides/physiology
  • Carrier Proteins/genetics/physiology
  • Drosophila melanogaster/genetics/immunology
  • Evolution, Molecular
  • Genes, Insect
  • Immunity, Innate/ genetics
  • Insect Proteins/genetics/physiology
  • Insect Vectors/ genetics/immunology
  • Malaria/transmission
  • Melanins/metabolism
  • Multigene Family
  • Signal Transduction
  • Species Specificity
Citation (ISO format)
WATERHOUSE, R. M. et al. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. In: Science, 2007, vol. 316, n° 5832, p. 1738–1743. doi: 10.1126/science.1139862
Main files (1)
ISSN of the journal0036-8075

Technical informations

Creation07/12/2010 2:36:37 PM
First validation07/12/2010 2:36:37 PM
Update time03/14/2023 3:54:08 PM
Status update03/14/2023 3:54:08 PM
Last indexation02/12/2024 6:59:13 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack