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Title

Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

Authors
Waterhouse, R. M.
Kriventseva, E. V.
Meister, Stephan
Xi, Zhiyong
Alvarez, K. S.
Bartholomay, L. C.
Barillas-Mury, Carolina
Bian, Guowu
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Published in Science. 2007, vol. 316, no. 5832, p. 1738-1743
Abstract Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
Keywords Aedes/ genetics/immunologyAnimalsAnopheles/ genetics/immunologyAntimicrobial Cationic Peptides/physiologyCarrier Proteins/genetics/physiologyDrosophila melanogaster/genetics/immunologyEvolution, MolecularGenes, InsectImmunity, Innate/ geneticsInsect Proteins/genetics/physiologyInsect Vectors/ genetics/immunologyMalaria/transmissionMelanins/metabolismMultigene FamilySignal TransductionSpecies Specificity
Identifiers
PMID: 17588928
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Research group Génomique Evolutionnaire Computationnelle (830)
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WATERHOUSE, R. M. et al. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. In: Science, 2007, vol. 316, n° 5832, p. 1738-1743. https://archive-ouverte.unige.ch/unige:9273

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Deposited on : 2010-07-12

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