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Title

Impact of environmental and genetic factors on codeine analgesia

Authors
Dayer, P
Magistris, M
Published in European Journal of Clinical Pharmacology. 1991, vol. 41, no. 1, p. 23-26
Abstract The polymorphic cytochrome P-450 DB1 (P-450 IID6) is responsible for the O-demethylation of codeine to morphine by human liver microsomes. The influence of P-450 DB1 variable activity on the bioactivation of codeine in vivo to morphine and on its analgesic effect was investigated in phenotyped healthy volunteers--7 extensive [EM] and 1 poor [PM] metabolizer of debrisoquine. After pretreatment with oral placebo or quinidine sulphate 50 mg, codeine phosphate 100 mg or placebo were administered orally according to a double-blind randomized crossover design. In EM subjects the plasma morphine Cmax was 17.9 nmol/l, whereas virtually no morphine was detectable after quinidine pretreatment (1.5 nmol/l), and in the PM subject (0.60 nmol/l). In EM codeine significantly increased subjective (VAS) and objective (R-III reflex) pain thresholds in response to selective transcutaneous nerve stimulation, whereas no significant analgesia was detected after placebo, or after codeine with quinidine pretreatment, or in the PM. In PM of genetic origin, or due to environmental alteration of the phenotypic expression (i.e. drug interaction), codeine is not activated into morphine and is an inefficient analgesic.
Keywords Administration, OralAdultBiotransformationCodeine/metabolism/pharmacologyCytochrome P-450 CYP2D6Cytochrome P-450 Enzyme System/metabolismFemaleHumansMaleMixed Function Oxygenases/metabolismMorphine/bloodPain Measurement/drug effects
Identifiers
PMID: 1782973
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Structures
Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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(ISO format)
DESMEULES, Jules Alexandre et al. Impact of environmental and genetic factors on codeine analgesia. In: European Journal of Clinical Pharmacology, 1991, vol. 41, n° 1, p. 23-26. https://archive-ouverte.unige.ch/unige:92729

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Deposited on : 2017-03-21

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