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Title

Quelle posologie antalgique du paracetamol?

Authors
Dayer, P
Published in Schweizerische medizinische Wochenschrift. 1994, vol. 124, no. 48, p. 2196-2198
Abstract The purpose of this study was to evaluate the dose-response of paracetamol and to assess its plasma concentration-effect relationship. According to a randomized, double-blind, and placebo controlled design healthy volunteers (n = 11) received 0.5, 1 and 2 g paracetamol (as propacetamol) intravenously (15 min). The extent of analgesic effect was measured over 8 hours by objective pain threshold (R-III) monitoring after selective transcutaneous electrical stimulation of the ipsilateral sural nerve. Maximal R-III threshold increase is at 2 hours after 0.5 g and 2.5 hours after 1 g and 2 g. The delayed peak effects, when compared to peak plasma concentrations, draw counter clockwise hysteresis. Duration of paracetamol antinociceptive effect increased concomitantly to dosage increment. Intravenous paracetamol exerts a dose-dependent central analgesia.
Keywords Acetaminophen/administration & dosage/bloodAdultCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodHumansMaleSural Nerve/drug effectsTranscutaneous Electric Nerve Stimulation
Identifiers
PMID: 7997863
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Structures
Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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PIGUET, Valérie et al. Quelle posologie antalgique du paracetamol?. In: Schweizerische medizinische Wochenschrift, 1994, vol. 124, n° 48, p. 2196-2198. https://archive-ouverte.unige.ch/unige:92712

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Deposited on : 2017-03-21

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