Chronic Δ⁹-tetrahydrocannabinol exposure induces a sensitization of dopamine D₂/₃ receptors in the mesoaccumbens and nigrostriatal systems
Published inNeuropsychopharmacology, vol. 37, no. 11, p. 2355-2367
Publication date2012
Abstract
Keywords
- Amphetamine/pharmacology
- Analysis of Variance
- Animals
- Basal Ganglia/diagnostic imaging/drug effects/metabolism
- Benzamides/pharmacokinetics
- Dopamine Agonists/pharmacology
- Dopamine Antagonists/pharmacokinetics
- Dopamine Uptake Inhibitors/pharmacology
- Dose-Response Relationship, Drug
- Dronabinol/pharmacology
- Drug Interactions
- Fluorodeoxyglucose F18/pharmacokinetics
- Gene Expression Regulation/drug effects
- Locomotion/drug effects
- Male
- Nucleus Accumbens/diagnostic imaging/drug effects/metabolism
- Positron-Emission Tomography
- Protein Binding/drug effects
- Psychotropic Drugs/pharmacology
- Quinpirole/pharmacology
- RNA, Messenger/metabolism
- Rats
- Rats, Sprague-Dawley
- Receptors, Dopamine D2/genetics/metabolism
- Tritium/pharmacokinetics
- Vitamin K 1/analogs & derivatives/pharmacokinetics
Affiliation entities
Funding
- Swiss National Science Foundation - Effects of a subchronic treatment with Delta9-tetrahydrocannabinol (THC) on behavior and in vivo dopamine function: a positron emission tomography study in rats
Citation (ISO format)
GINOVART, Nathalie et al. Chronic Δ⁹-tetrahydrocannabinol exposure induces a sensitization of dopamine D₂/₃ receptors in the mesoaccumbens and nigrostriatal systems. In: Neuropsychopharmacology, 2012, vol. 37, n° 11, p. 2355–2367. doi: 10.1038/npp.2012.91
Main files (1)
Article (Published version)
Identifiers
- PID : unige:92656
- DOI : 10.1038/npp.2012.91
- PMID : 22692568
Journal ISSN0893-133X