The MAPT gene is differentially methylated in the progressive supranuclear palsy brain

Huin, Vincent; Deramecourt, Vincent; Caparros-Lefebvre, Dominique; Maurage, Claude-Alain; Duyckaerts, Charles; Kovari, Eniko Veronika; Pasquier, Florence; Buée-Scherrer, Valérie; Labreuche, Julien; Behal, Hélène; Buée, Luc; Dhaenens, Claire-Marie; Sablonnière, Bernard

doi:10.1002/mds.26820

Scientific article

English

The MAPT gene is differentially methylated in the progressive supranuclear palsy brain

ContributorsHuin, Vincent; Deramecourt, Vincent; Caparros-Lefebvre, Dominique; Maurage, Claude-Alain; Duyckaerts, Charles; Kovari, Eniko Veronika; Pasquier, Florence; Buée-Scherrer, Valérie; Labreuche, Julien; Behal, Hélène; Buée, Luc; Dhaenens, Claire-Marie; Sablonnière, Bernard

Published inMovement disorders, vol. 31, no. 12, p. 1883-1890

Publication date2016

Abstract

Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes in Alzheimer's disease and Parkinson's disease brains. However, few studies examine the sequences beyond the constitutive promoter.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Neuroimagerie moléculaire en psychiatrie (983)

Citation (ISO format)

HUIN, Vincent et al. The MAPT gene is differentially methylated in the progressive supranuclear palsy brain. In: Movement disorders, 2016, vol. 31, n° 12, p. 1883–1890. doi: 10.1002/mds.26820

Article (Published version)

Identifiers

PID : unige:92642
DOI : 10.1002/mds.26820
PMID : 27709663

Journal ISSN0885-3185

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The MAPT gene is differentially methylated in the progressive supranuclear palsy brain

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