UNIGE document Scientific Article
previous document  unige:9226  next document
add to browser collection

High incidence of ectopic nucleolar organizer regions in human testicular tumors

Delozier-Blanchet, C. D.
Bolle, J. F.
Rondez, R.
Published in Cancer genetics and cytogenetics. 1993, vol. 65, no. 1, p. 58-63
Abstract Eight primary testicular germ cell tumors, one teratocarcinoma cell line, and one Leydig cell tumor were studied to determine the importance of modifications of the nucleolar organizer regions (NORs) in human testicular tumors. Cytogenetic analysis after silver staining showed active ectopic NORs in two primary embryonal carcinomas (EC) in the cell line and in single cells of each of two seminomas (S). In one EC, an ectopic NOR was localized to chromosomal region 1q4; the others were on unidentified rearranged chromosomes. All tumors in which ectopic NORs were observed were hyperdiploid and possessed marker chromosomes typical of human germ cell tumors. Quantitative DNA analysis was performed on three tumors: a teratocarcinoma (TC) and the Leydig cell tumor, which had provided no analyzable mitoses, and a seminoma which was cytogenetically diploid. In all three cases, the major populations were hyperdiploid. The results, in combination with those of an earlier study, provide evidence that active ectopic NORs are common in human testicular tumors.
Keywords AneuploidyBlotting, SouthernChromosome AberrationsChromosomes, Human, Pair 1Chromosomes, Human, Pair 12DNA, Neoplasm/analysisDysgerminoma/geneticsHumansKaryotypingLeydig Cell Tumor/geneticsMaleNeoplasms, Germ Cell and Embryonal/ geneticsNucleolus Organizer Region/ pathologySilver NitrateTeratoma/geneticsTesticular Neoplasms/ geneticsTumor Cells, Cultured
PMID: 8381712
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
(ISO format)
NEERMAN ARBEZ, Marguerite et al. High incidence of ectopic nucleolar organizer regions in human testicular tumors. In: Cancer genetics and cytogenetics, 1993, vol. 65, n° 1, p. 58-63. doi: 10.1016/0165-4608(93)90059-u https://archive-ouverte.unige.ch/unige:9226

484 hits

0 download


Deposited on : 2010-07-12

Export document
Format :
Citation style :