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In vitro whole-genome analysis identifies a susceptibility locus for HIV-1

Loeuillet, Corinne
Deutsch, Samuel
Ciuffi, Angela
Munoz, Miguel
Beckmann, J. S.
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Published in PLoS biology. 2008, vol. 6, no. 2, e32
Abstract Advances in large-scale analysis of human genomic variability provide unprecedented opportunities to study the genetic basis of susceptibility to infectious agents. We report here the use of an in vitro system for the identification of a locus on HSA8q24.3 associated with cellular susceptibility to HIV-1. This locus was mapped through quantitative linkage analysis using cell lines from multigeneration families, validated in vitro, and followed up by two independent association studies in HIV-positive individuals. Single nucleotide polymorphism rs2572886, which is associated with cellular susceptibility to HIV-1 in lymphoblastoid B cells and in primary T cells, was also associated with accelerated disease progression in one of two cohorts of HIV-1-infected patients. Biological analysis suggests a role of the rs2572886 region in the regulation of the LY6 family of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins. Genetic analysis of in vitro cellular phenotypes provides an attractive approach for the discovery of susceptibility loci to infectious agents.
Keywords Chromosome MappingCohort StudiesGenetic Predisposition to DiseaseGenome, HumanGlycosylphosphatidylinositols/geneticsHIV Infections/ geneticsHIV-1/ physiologyHumans
PMID: 18288889
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LOEUILLET, Corinne et al. In vitro whole-genome analysis identifies a susceptibility locus for HIV-1. In: PLoS biology, 2008, vol. 6, n° 2, p. e32. doi: 10.1371/journal.pbio.0060032 https://archive-ouverte.unige.ch/unige:9214

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Deposited on : 2010-07-12

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