The paired-pulse transcranial magnetic stimulation (TMS) paradigms allow the exploration of the motor cortex physiology. The Triple Stimulation Technique (TST) improves conventional TMS by reducing effects of de-synchronization of motor neuron discharges allowing a precise evaluation of the cortico-spinal conduction. The objective of our study was to explore paired-pulse (PP) TMS paradigms combined with the TST in order to study whether the de-synchronization contributes to these phenomena and whether the combined TMS-TST protocol could improve the consistency of responses. We investigated the PP paradigms of short intra-cortical inhibition (SICI) with 2 ms inter-stimulus interval (ISI) and of intra-cortical facilitation (ICF) with 10 ms ISI in 22 healthy subjects applying either conventional TMS alone or combined with the TST protocol. The results of the PP paradigms combined with the TST of SICI and ICF do not differ from those with conventional TMS. But, combining the PP paradigm with the TST reduces their variability. These results do not suggest a contribution of the de-synchronization of motor neuron discharges to the paired-pulse paradigms of short intra-cortical inhibition and facilitation. Combining the PP TMS paradigm with the TST may improve their consistency, but the inter-individual variability precludes their utility for clinical practice.