A whole-genome association study of major determinants for host control of HIV-1

Fellay, Jacques; Shianna, K. V.; Ge, Dongliang; Colombo, Sara; Ledergerber, Bruno; Weale, Mike; Zhang, Kunlin; Gumbs, Curtis; Castagna, Antonella; Cossarizza, Andrea; Cozzi-Lepri, Alessandro; De Luca, Andrea; Easterbrook, Philippa; Francioli, Patrick; Mallal, Simon; Martinez-Picado, Javier; Miro, J. M.; Obel, Niels; Smith, J. P.; Wyniger, Josiane; Descombes, Patrick; Antonarakis, Stylianos; Letvin, N. L.; McMichael, A. J.; Haynes, B. F.; Telenti, Amalio; Goldstein, D. B.

doi:10.1126/science.1143767

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Title		A whole-genome association study of major determinants for host control of HIV-1
Authors		Fellay, Jacques Shianna, K. V. Ge, Dongliang Colombo, Sara Ledergerber, Bruno Weale, Mike Zhang, Kunlin Gumbs, Curtis Castagna, Antonella Cossarizza, Andrea Cozzi-Lepri, Alessandro De Luca, Andrea Easterbrook, Philippa Francioli, Patrick Mallal, Simon Martinez-Picado, Javier Miro, J. M. Obel, Niels Smith, J. P. Wyniger, Josiane Descombes, Patrick Antonarakis, Stylianos Letvin, N. L. McMichael, A. J. Haynes, B. F. Telenti, Amalio Goldstein, D. B. show all authors [1 - 27]
Published in		Science. 2007, vol. 317, no. 5840, p. 944-947
Abstract		Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Keywords		Cohort Studies — DNA-Binding Proteins/genetics — Disease Progression — Female — Genes, MHC Class I — Genome, Human — HIV Infections/ genetics/immunology/therapy/ virology — HIV-1/ physiology — HLA-B Antigens/ genetics — HLA-C Antigens/ genetics — Haplotypes — Humans — Immediate-Early Proteins/genetics — Major Histocompatibility Complex/ genetics — Male — Polymorphism, Single Nucleotide — Regression Analysis — Viral Load
Identifiers		DOI: 10.1126/science.1143767 PMID: 17641165
Full text		Article (Published version) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Citation (ISO format)		FELLAY, Jacques et al. A whole-genome association study of major determinants for host control of HIV-1. In: Science, 2007, vol. 317, n° 5840, p. 944-947. doi: 10.1126/science.1143767 https://archive-ouverte.unige.ch/unige:9171