en
Scientific article
Open access
English

A whole-genome association study of major determinants for host control of HIV-1

Published inScience, vol. 317, no. 5840, p. 944-947
Publication date2007
Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.

Keywords
  • Cohort Studies
  • DNA-Binding Proteins/genetics
  • Disease Progression
  • Female
  • Genes, MHC Class I
  • Genome, Human
  • HIV Infections/ genetics/immunology/therapy/ virology
  • HIV-1/ physiology
  • HLA-B Antigens/ genetics
  • HLA-C Antigens/ genetics
  • Haplotypes
  • Humans
  • Immediate-Early Proteins/genetics
  • Major Histocompatibility Complex/ genetics
  • Male
  • Polymorphism, Single Nucleotide
  • Regression Analysis
  • Viral Load
Citation (ISO format)
FELLAY, Jacques et al. A whole-genome association study of major determinants for host control of HIV-1. In: Science, 2007, vol. 317, n° 5840, p. 944–947. doi: 10.1126/science.1143767
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0036-8075
640views
716downloads

Technical informations

Creation07/12/2010 2:36:11 PM
First validation07/12/2010 2:36:11 PM
Update time03/14/2023 3:53:43 PM
Status update03/14/2023 3:53:43 PM
Last indexation01/15/2024 8:47:37 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack