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A whole-genome association study of major determinants for host control of HIV-1

Fellay, Jacques
Shianna, K. V.
Ge, Dongliang
Colombo, Sara
Ledergerber, Bruno
Weale, Mike
Zhang, Kunlin
Gumbs, Curtis
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Published in Science. 2007, vol. 317, no. 5840, p. 944-947
Abstract Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Keywords Cohort StudiesDNA-Binding Proteins/geneticsDisease ProgressionFemaleGenes, MHC Class IGenome, HumanHIV Infections/ genetics/immunology/therapy/ virologyHIV-1/ physiologyHLA-B Antigens/ geneticsHLA-C Antigens/ geneticsHaplotypesHumansImmediate-Early Proteins/geneticsMajor Histocompatibility Complex/ geneticsMalePolymorphism, Single NucleotideRegression AnalysisViral Load
PMID: 17641165
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FELLAY, Jacques et al. A whole-genome association study of major determinants for host control of HIV-1. In: Science, 2007, vol. 317, n° 5840, p. 944-947. doi: 10.1126/science.1143767 https://archive-ouverte.unige.ch/unige:9171

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Deposited on : 2010-07-12

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