en
Doctoral thesis
Open access
English

Regulatory role of B cell-derived transforming growth factor-β1 expression in autoimmune neuroinflammation

Defense date2016-12-12
Abstract

Data indicate a role for TGF-β1 expression in regulatory B cell functions, although this mechanism has not been tested in autoimmune neuroinflammation. Transgenic mice deficient for TGF-β1 expression in B cells (B–TGF-β1–/–) were tested in EAE induced by recombinant mouse MOG (rmMOG) or adoptive transfer EAE (at-EAE). In rmMOG EAE, B–TGF-β1–/– mice showed an earlier disease onset compared to littermate controls. Exacerbated EAE susceptibility was associated with augmented CNS T helper cell responses. Additionally, selective B cell TGF-β1–deficiency increased the frequencies and activation of myeloid DCs. Lack of TGF-β1 production by B cells did not influence the EAE course in at-EAE. Collectively our data suggest that in rmMOG EAE B cells can regulate the function of APCs, and in turn encephalitogenic Th1/17 responses, via TGF-β1. An in vitro study of human B cells further indicated that TGF-β1 is downregulated when B cells are activated.

eng
Keywords
  • B cells
  • Regulatory
  • EAE
  • MS
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Dendritic cells
  • DCs
  • T cells
  • Th17
  • Th1
  • Regulatory B cells
  • TGF-b1
  • Transforming growth factor b1
Citation (ISO format)
BJARNADOTTIR, Kristbjorg. Regulatory role of B cell-derived transforming growth factor-β1 expression in autoimmune neuroinflammation. 2016. doi: 10.13097/archive-ouverte/unige:91629
Main files (1)
Thesis
accessLevelPublic
Identifiers
505views
133downloads

Technical informations

Creation01/17/2017 6:46:00 PM
First validation01/17/2017 6:46:00 PM
Update time03/15/2023 1:21:11 AM
Status update03/15/2023 1:21:11 AM
Last indexation05/02/2024 6:09:00 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack