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Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes

Busso, N.
Published in Experimental Cell Research. 1987, vol. 173, no. 2, p. 425-430
Abstract The effect of RU 486, a synthetic steroid that is a powerful antagonist of glucocorticoid hormones, was tested on the transcription of several glucocorticoid-regulated genes in different cell types: inflammatory murine macrophages and two human mammary gland-derived cell lines, MDA-MB-231 and HBL-100. The transcription of genes which are positively regulated by glucocorticoids (e.g., tissue-type plasminogen activator and c-myc in mammary cells, c-fos in macrophages) and that of genes which are negatively regulated by these agents (e.g., urokinase-type plasminogen activator in all three cell types, TNF-a and IL-1 in macrophages) was explored. RU 486 almost completely prevented the effects of dexamethasone on the transcription of these various genes. When added alone, RU 486 had essentially no agonist activity.
Keywords AnimalsCell Line, TransformedDexamethasone/ antagonists & inhibitors/pharmacologyEstrenes/ pharmacologyHumansInterleukin-1/geneticsMacrophages/enzymologyMiceMifepristonePlasminogen Activators/ genetics/metabolismRNA, Messenger/biosynthesisTissue Plasminogen Activator/ genetics/metabolismTranscription, Genetic/ drug effectsTumor Cells, CulturedTumor Necrosis Factor-alpha/geneticsUrokinase-Type Plasminogen Activator/ genetics/metabolism
PMID: 3121370
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BUSSO, N. et al. Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes. In: Experimental Cell Research, 1987, vol. 173, n° 2, p. 425-430. https://archive-ouverte.unige.ch/unige:9149

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Deposited on : 2010-07-12

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