Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes
|Published in||Experimental Cell Research. 1987, vol. 173, no. 2, p. 425-430|
|Abstract||The effect of RU 486, a synthetic steroid that is a powerful antagonist of glucocorticoid hormones, was tested on the transcription of several glucocorticoid-regulated genes in different cell types: inflammatory murine macrophages and two human mammary gland-derived cell lines, MDA-MB-231 and HBL-100. The transcription of genes which are positively regulated by glucocorticoids (e.g., tissue-type plasminogen activator and c-myc in mammary cells, c-fos in macrophages) and that of genes which are negatively regulated by these agents (e.g., urokinase-type plasminogen activator in all three cell types, TNF-a and IL-1 in macrophages) was explored. RU 486 almost completely prevented the effects of dexamethasone on the transcription of these various genes. When added alone, RU 486 had essentially no agonist activity.|
|Keywords||Animals — Cell Line, Transformed — Dexamethasone/ antagonists & inhibitors/pharmacology — Estrenes/ pharmacology — Humans — Interleukin-1/genetics — Macrophages/enzymology — Mice — Mifepristone — Plasminogen Activators/ genetics/metabolism — RNA, Messenger/biosynthesis — Tissue Plasminogen Activator/ genetics/metabolism — Transcription, Genetic/ drug effects — Tumor Cells, Cultured — Tumor Necrosis Factor-alpha/genetics — Urokinase-Type Plasminogen Activator/ genetics/metabolism|
This document has no fulltext available yet, but you can contact its author by using the form below.
|BUSSO, N. et al. Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes. In: Experimental Cell Research, 1987, vol. 173, n° 2, p. 425-430. https://archive-ouverte.unige.ch/unige:9149|