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The receptor for urokinase-type plasminogen activator is expressed during mouse spermatogenesis

Zhou, H.
Published in FEBS Letters. 1997, vol. 413, no. 1, p. 11-15
Abstract Urokinase-type plasminogen activator (uPA) binds to a plasma membrane receptor (uPAR) that localizes plasmin generation to the cell environment. Mouse spermatozoa have surface-bound uPA, which appears to be acquired from genital tract secretions at ejaculation. We determined the presence of uPAR mRNA in spermatogenic cells and their uPA-binding activity. Northern blot and in situ hybridization demonstrated the presence of uPAR mRNA in germ cells. Binding of uPA, but not of a mutant enzyme lacking the receptor-binding domain, indicated the presence of uPAR on spermatids and spermatozoa. The uPAR and/or receptor-bound uPA may be involved in spermatogenesis, spermatozoa maturation or fertilization.
Keywords AnimalsBlotting, NorthernGerm Cells/metabolismIn Situ HybridizationMaleMiceMice, KnockoutPlasminogen Activators/deficiency/ metabolismRNA, Messenger/metabolismReceptors, Cell Surface/deficiency/ metabolismReceptors, Urokinase Plasminogen ActivatorSpermatids/metabolismSpermatogenesisSpermatozoa/metabolism
PMID: 9287108
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ZHOU, H., VASSALLI, Jean-Dominique. The receptor for urokinase-type plasminogen activator is expressed during mouse spermatogenesis. In: FEBS Letters, 1997, vol. 413, n° 1, p. 11-15. doi: 10.1016/s0014-5793(97)00861-2 https://archive-ouverte.unige.ch/unige:9113

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Deposited on : 2010-07-12

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