UNIGE document Scientific Article
previous document  unige:91052  next document
add to browser collection
Title

Mapping human skeletal muscle perforator vessels using a quantum well infrared photodetector (QWIP) might explain the variability of NIRS and LDF measurements

Authors
Leung, T
Delpy, D T
Fauci, M A
Published in Physics in Medicine and Biology. 2004, vol. 49, no. 12, p. N165-N173
Abstract Near-infrared spectroscopy (NIRS) and laser Doppler flowmetry (LDF) have become the techniques of choice allowing the non-invasive study of local human skeletal muscle metabolism and blood perfusion on a small tissue volume (a few cm3). However, it has been shown that both NIRS and LDF measurements may show a large spatial variability depending on the position of the optodes over the investigated muscle. This variability may be due to local morphologic and/or metabolic characteristics of the muscle and makes the data interpretation and comparison difficult. In the present work, we use a third method to investigate this problem which permits fast, non-invasive mapping of the intramuscular vessel distribution in the human vastus latelralis muscle. This method uses an advanced, passive, infrared imaging sensor called a QWIP (quantum well infrared photodetector). We demonstrate, using a recovery-enhanced infrared imaging technique, that there is a significant presence of perforator vessels in the region of interest of approximately 30 x 18 cm (the number of vessels being: 14, 9, 8, 33, 17 and 18 for each subject, respectively). The presence of these vessels makes the skeletal muscle highly inhomogeneous, and may explain the observed NIRS and LDF spatial variability. We conclude that accurate comparison of the metabolic activity of two different muscle regions is not possible without reliable maps of vascular 'singularities' such as the perforator vessels, and that the QWIP-based imaging system is one method to obtain this information.
Keywords AdultBlood Flow Velocity/physiologyEquipment Failure AnalysisHumansLaser-Doppler Flowmetry/methodsMaleMuscle, Skeletal/blood supply/physiologyRegional Blood Flow/physiologyReproducibility of ResultsSensitivity and SpecificitySpectrophotometry, Infrared/methodsTransducers
Identifiers
PMID: 15272688
Full text
Article (Published version) (293 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Binzoni Tiziano (radiologie) (234)
Citation
(ISO format)
BINZONI, Tiziano et al. Mapping human skeletal muscle perforator vessels using a quantum well infrared photodetector (QWIP) might explain the variability of NIRS and LDF measurements. In: Physics in Medicine and Biology, 2004, vol. 49, n° 12, p. N165-N173. https://archive-ouverte.unige.ch/unige:91052

30 hits

0 download

Update

Deposited on : 2017-01-13

Export document
Format :
Citation style :