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Absorption and scattering coefficient dependence of laser-Doppler flowmetry models for large tissue volumes

Leung, T S
Delpy, D T
Published in Physics in Medicine and Biology. 2006, vol. 51, no. 2, p. 311-333
Abstract Based on quasi-elastic scattering theory (and random walk on a lattice approach), a model of laser-Doppler flowmetry (LDF) has been derived which can be applied to measurements in large tissue volumes (e.g. when the interoptode distance is >30 mm). The model holds for a semi-infinite medium and takes into account the transport-corrected scattering coefficient and the absorption coefficient of the tissue, and the scattering coefficient of the red blood cells. The model holds for anisotropic scattering and for multiple scattering of the photons by the moving scatterers of finite size. In particular, it has also been possible to take into account the simultaneous presence of both Brownian and pure translational movements. An analytical and simplified version of the model has also been derived and its validity investigated, for the case of measurements in human skeletal muscle tissue. It is shown that at large optode spacing it is possible to use the simplified model, taking into account only a 'mean' light pathlength, to predict the blood flow related parameters. It is also demonstrated that the 'classical' blood volume parameter, derived from LDF instruments, may not represent the actual blood volume variations when the investigated tissue volume is large. The simplified model does not need knowledge of the tissue optical parameters and thus should allow the development of very simple and cost-effective LDF hardware.
Keywords AbsorptionComputer SimulationErythrocytes/chemistryHumansLaser-Doppler FlowmetryModels, BiologicalScattering, Radiation
PMID: 16394341
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Research group Groupe Binzoni Tiziano (radiologie) (234)
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BINZONI, Tiziano et al. Absorption and scattering coefficient dependence of laser-Doppler flowmetry models for large tissue volumes. In: Physics in Medicine and Biology, 2006, vol. 51, n° 2, p. 311-333. doi: 10.1088/0031-9155/51/2/009 https://archive-ouverte.unige.ch/unige:91044

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Deposited on : 2017-01-13

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