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Title

Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy

Authors
Kayser, V
Published in Pain. 1995, vol. 60, no. 3, p. 275-285
Abstract The antinociceptive action of the systemically administered alpha 2-adrenoceptor agonist clonidine was evaluated in a rat model of peripheral unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve, using nociceptive tests based on mechanical (vocalization threshold to paw pressure) or thermal (struggle latency to paw immersion in a cold (10 degrees C) or hot (44 degrees C) water bath) stimuli. Experiments were performed 2-3 weeks after surgery when pain-related behavior was fully developed. We demonstrated a dissociative action depending on the test used: clonidine (30-100 micrograms/kg i.v.) had a moderate effect on the abnormal reactions to the mechanical stimulus. By contrast it dramatically increased the struggle latency to hot or cold stimuli. These latter effects were completely prevented by prior administration of the alpha 2-adrenoceptor antagonist idazoxan (0.5 mg/kg i.v.).
Keywords Adrenergic alpha-Antagonists/pharmacologyAnalysis of VarianceAnimalsClonidine/antagonists & inhibitors/pharmacologyCold TemperatureDioxanes/pharmacologyDisease Models, AnimalHot TemperatureIdazoxanInjections, IntravenousMalePain/drug therapy/etiologyPeripheral Nervous System Diseases/complicationsRatsRats, Sprague-DawleyReaction Time/drug effectsStress, Mechanical
Identifiers
PMID: 7596623
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Structures
Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation
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KAYSER, V, DESMEULES, Jules Alexandre, GUILBAUD, Georges Silvain. Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy. In: Pain, 1995, vol. 60, n° 3, p. 275-285. https://archive-ouverte.unige.ch/unige:90892

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Deposited on : 2017-01-06

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