Scientific article

Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex

Published inEuropean journal of clinical pharmacology, vol. 53, no. 5, p. 321-324
Publication date1998

The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive flexion reflex threshold (R-III) in response to selective transcutaneous electrical stimulations.

  • Acetaminophen/administration & dosage/blood/pharmacology
  • Adult
  • Analgesics, Non-Narcotic/administration & dosage/blood/pharmacology
  • Area Under Curve
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Humans
  • Injections, Intravenous
  • Male
  • Pain Measurement/drug effects
  • Pain Threshold/drug effects
Citation (ISO format)
PIGUET, Valérie, DESMEULES, Jules Alexandre, DAYER, Pierre. Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex. In: European journal of clinical pharmacology, 1998, vol. 53, n° 5, p. 321–324.
Main files (1)
Article (Published version)
ISSN of the journal0031-6970

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