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Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex

Published in European journal of clinical pharmacology. 1998, vol. 53, no. 5, p. 321-324
Abstract The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive flexion reflex threshold (R-III) in response to selective transcutaneous electrical stimulations.
Keywords Acetaminophen/administration & dosage/blood/pharmacologyAdultAnalgesics, Non-Narcotic/administration & dosage/blood/pharmacologyArea Under CurveDose-Response Relationship, DrugDouble-Blind MethodHumansInjections, IntravenousMalePain Measurement/drug effectsPain Threshold/drug effects
PMID: 9516030
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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PIGUET, Valérie, DESMEULES, Jules Alexandre, DAYER, Pierre. Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex. In: European journal of clinical pharmacology, 1998, vol. 53, n° 5, p. 321-324. https://archive-ouverte.unige.ch/unige:90860

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Deposited on : 2017-01-04

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