An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events
Published inDiabetologia, vol. 45, no. 5, p. 657-667
Publication date2002
Abstract
Keywords
- Acanthosis Nigricans/genetics
- Adult
- Amino Acid Substitution
- Animals
- Arginine
- CHO Cells
- Cricetinae
- Cysteine
- DNA/biosynthesis
- Humans
- Insulin/metabolism
- Insulin Resistance/genetics
- Male
- Mitogen-Activated Protein Kinase 1/metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases/metabolism
- Mutation
- Phosphorylation
- Protein Subunits
- Protein Transport
- Receptor
- Insulin/genetics/metabolism/physiology
- Recombinant Proteins/metabolism
- Signal Transduction/physiology
- Thymidine/metabolism
- Transfection
Research groups
Citation (ISO format)
HAMER, Isabelle et al. An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events. In: Diabetologia, 2002, vol. 45, n° 5, p. 657–667. doi: 10.1007/s00125-002-0798-5
Main files (1)
Article (Published version)
Identifiers
- PID : unige:90658
- DOI : 10.1007/s00125-002-0798-5
- PMID : 12107746
Journal ISSN0012-186X
