UNIGE document Scientific Article
previous document  unige:90658  next document
add to browser collection
Title

An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events

Authors
Emkey, R
Cordier-Bussat, M
De Meyts, P
Kahn, C R
show hidden authors show all authors [1 - 9]
Published in Diabetologia. 2002, vol. 45, no. 5, p. 657-667
Abstract We examined the properties of a mutant insulin receptor (IR) with an Arg(252) to Cys (IR(R252C)) substitution in the alpha-subunit originally identified in a patient with extreme insulin resistance and acanthosis nigricans.
Keywords Acanthosis Nigricans/geneticsAdultAmino Acid SubstitutionAnimalsArginineCHO CellsCricetinaeCysteineDNA/biosynthesisHumansInsulin/metabolismInsulin Resistance/geneticsMaleMitogen-Activated Protein Kinase 1/metabolismMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinases/metabolismMutationPhosphorylationProtein SubunitsProtein TransportReceptorInsulin/genetics/metabolism/physiologyRecombinant Proteins/metabolismSignal Transduction/physiologyThymidine/metabolismTransfection
Identifiers
PMID: 12107746
Full text
Article (Published version) (728 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Obésité et syndrome métabolique (803)
Citation
(ISO format)
HAMER, Isabelle et al. An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events. In: Diabetologia, 2002, vol. 45, n° 5, p. 657-667. https://archive-ouverte.unige.ch/unige:90658

30 hits

0 download

Update

Deposited on : 2016-12-21

Export document
Format :
Citation style :