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Title

Comparison of survival outcomes between Expanded Criteria Donor and Standard Criteria Donor kidney transplant recipients: a systematic review and meta-analysis

Authors
Querard, Anne-Hélène
Foucher, Yohann
Dantan, Etienne
Larmet, David
Lorent, Marine
Pouteau, Lise-Marie
Giral, Magali
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Published in Transplant International. 2016, vol. 29, no. 4, p. 403-415
Abstract In 2002, the United Network for Organ Sharing proposed increasing the pool of donor kidneys to include Expanded Criteria Donor (ECD). Outside the USA, the ECD definition remains the one used without questioning whether such a graft allocation criterion is valid worldwide. We performed a meta-analysis to quantify the differences between ECD and Standard Criteria Donor (SCD) transplants. We paid particular attention to select studies in which the methodology was appropriate and we took into consideration the geographical area. Thirty-two publications were included. Only five studies, all from the USA, reported confounder-adjusted hazard ratios comparing the survival outcomes between ECD and SCD kidney transplant recipients. These five studies confirmed that ECD recipients seemed to have poorer prognosis. From 29 studies reporting appropriate survival curves, we estimated the 5-year pooled nonadjusted survivals for ECD and SCD recipients. The relative differences between the two groups were lower in Europe than in North America, particularly for death-censored graft failure. It is of primary importance to propose appropriate studies for external validation of the ECD criteria in non-US kidney transplant recipients.
Identifiers
PMID: 26756928
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Research group Epidémiologie clinique (115)
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QUERARD, Anne-Hélène et al. Comparison of survival outcomes between Expanded Criteria Donor and Standard Criteria Donor kidney transplant recipients: a systematic review and meta-analysis. In: Transplant International, 2016, vol. 29, n° 4, p. 403-415. https://archive-ouverte.unige.ch/unige:90601

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Deposited on : 2016-12-21

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