Genetic studies of body mass index yield new insights for obesity biology
|Published in||Nature. 2015, vol. 518, no. 7538, p. 197-206|
|Abstract||Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.|
|Keywords||Adipogenesis/genetics — Adiposity/genetics — Age Factors — Body Mass Index — Continental Population Groups/genetics — Energy Metabolism/genetics — Europe/ethnology — Female — Genetic Predisposition to Disease/genetics — Genome-Wide Association Study — Glutamic Acid/metabolism — Humans — Insulin/metabolism/secretion — Male — Obesity/genetics/metabolism — Polymorphism, Single Nucleotide/genetics — Quantitative Trait Loci/genetics — Synapses/metabolism|
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|Research group||Traits génétiques complexes (901)|
|LOCKE, Adam E et al. Genetic studies of body mass index yield new insights for obesity biology. In: Nature, 2015, vol. 518, n° 7538, p. 197-206. doi: 10.1038/nature14177 https://archive-ouverte.unige.ch/unige:90584|