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Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas

Barber, Melissa
Arai, Yoko
Morishita, Yoshihiro
Vigier, Lisa
Causeret, Frédéric
Borello, Ugo
Ledonne, Fanny
Coppola, Eva
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Published in Current biology. 2015, vol. 25, no. 19, p. 2466-2478
Abstract In the neocortex, higher-order areas are essential to integrate sensory-motor information and have expanded in size during evolution. How higher-order areas are specified, however, remains largely unknown. Here, we show that the migration and distribution of early-born neurons, the Cajal-Retzius cells (CRs), controls the size of higher-order areas in the mouse somatosensory, auditory, and visual cortex. Using live imaging, genetics, and in silico modeling, we show that subtype-specific differences in the onset, speed, and directionality of CR migration determine their differential invasion of the developing cortical surface. CR migration speed is cell autonomously modulated by vesicle-associated membrane protein 3 (VAMP3), a classically non-neuronal mediator of endosomal recycling. Increasing CR migration speed alters their distribution in the developing cerebral cortex and leads to an expansion of postnatal higher-order areas and congruent rewiring of thalamo-cortical input. Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring.
Keywords AnimalsCell Movement/physiologyCerebral Cortex/cytology/physiologyInterstitial Cells of Cajal/cytology/physiologyMiceMice, TransgenicModels, BiologicalNeocortex/cytology/metabolism/physiologyNeurons/metabolismVesicle-Associated Membrane Protein 3/metabolism
PMID: 26387718
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Research group Neurobiologie développementale et plasticité (880)
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BARBER, Melissa et al. Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. In: Current biology, 2015, vol. 25, n° 19, p. 2466-2478. doi: 10.1016/j.cub.2015.08.028 https://archive-ouverte.unige.ch/unige:90579

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Deposited on : 2016-12-20

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