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English

How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

Contributors

Gayet-Ageron, Angèle; Jannot Berthier, Anne-Sophie; Agoritsas, Thomas; Rudaz, Sandrine; Combescure, Christophe; Perneger, Thomas

Published in

BMC Medical research methodology, vol. 16, 89

Publication date

2016

Abstract

There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outcome, patient age group, and presence of treatment side-effects), and 3 that should not (baseline level of risk, logistical difficulties, and cost of treatment).

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

GAYET-AGERON, Angèle et al. How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers. In: BMC Medical research methodology, 2016, vol. 16, p. 89. doi: 10.1186/s12874-016-0195-2

Main files (1)

Article (Published version)
CC BY

Identifiers

Journal ISSN

1471-2288
536views
244downloads

Technical informations

Creation

18/11/2016 10:21:00

First validation

18/11/2016 10:21:00

Update

15/03/2023 01:11:02

Status update

15/03/2023 01:11:01

Last indexation

14/03/2025 17:05:24
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