Scientific article

English

How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

ContributorsGayet-Ageron, Angèle

; Jannot Berthier, Anne-Sophie; Agoritsas, Thomas

; Rudaz, Sandrine; Combescure, Christophe

; Perneger, Thomas

Published inBMC Medical research methodology, vol. 16, 89

Publication date2016

Abstract

There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outcome, patient age group, and presence of treatment side-effects), and 3 that should not (baseline level of risk, logistical difficulties, and cost of treatment).

Affiliation entities

Research groups

Epidémiologie clinique (115)

Citation (ISO format)

GAYET-AGERON, Angèle et al. How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers. In: BMC Medical research methodology, 2016, vol. 16, p. 89. doi: 10.1186/s12874-016-0195-2

Article (Published version)

Identifiers

PID : unige:90403
DOI : 10.1186/s12874-016-0195-2
PMID : 27473336

Journal ISSN1471-2288

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Creation18/11/2016 10:21:00

First validation18/11/2016 10:21:00

Update15/03/2023 01:11:02

Status update15/03/2023 01:11:01

Last indexation14/03/2025 17:05:24