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Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis

Burlet, Nansa
Cahall, David
Delmas, Pierre D.
Eriksen, Erik Fink
Felsenberg, Dieter
Grbic, John
Jontell, Mats
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Published in Bone. 2008, vol. 42, no. 5, p. 841-7
Abstract A potential side effect associated with bisphosphonates, a class of drugs used in the treatment of osteoporosis, Paget's disease and metastatic bone disease, is osteonecrosis of the jaw (ONJ). The incidence of ONJ in the general population is unknown; this rare condition also may occur in patients not receiving bisphosphonates. Case reports have discussed ONJ development in patients with multiple myeloma or metastatic breast cancer receiving bisphosphonates as palliation for bone metastases. These patients are also receiving chemotherapeutic agents that might impair the immune system and affect angiogenesis. The incidence or prevalence of ONJ in patients taking bisphosphonates for osteoporosis seems to be very rare. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy. A majority of ONJ occurs after tooth extraction. Furthermore, the underlying risk of developing ONJ may be increased in osteoporotic patients by comorbid diseases. Treatment for ONJ is generally conservative.
Keywords Diphosphonatess/adverse effects/therapeutic useHumansJaw Diseases/chemically induced/therapyOsteitis Deformans/drug therapyOsteonecrosis/chemically induced/therapyOsteoporosis/drug therapyRisk Factors
PMID: 18314405
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Research group Nutrition et os (66)
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RIZZOLI, René et al. Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. In: Bone, 2008, vol. 42, n° 5, p. 841-7. https://archive-ouverte.unige.ch/unige:904

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Deposited on : 2009-02-24

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