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Title

Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells

Authors
Tien, Thomas
Barrette, Kevin F
Roy, Sayon
Published in Investigative Ophthalmology and Visual Science, IOVS. 2013, vol. 54, no. 10, p. 6518-25
Abstract To investigate whether high glucose (HG)-induced downregulation of connexin 43 (Cx43), a gap junction protein, alters ZO-1 and occludin expression and cell monolayer permeability.
Keywords AnimalsBlottingWesternCell Communication/drug effects/geneticsCellsCulturedConnexin 43/biosynthesis/drug effects/geneticsDiabetes MellitusExperimentalDiabetic Retinopathy/genetics/metabolism/pathologyDown-Regulation/drug effectsEpithelial Cells/drug effects/metabolism/pathologyGlucose/pharmacologyOccludin/biosynthesis/drug effects/geneticsRNAMessenger/geneticsRatsRetina/drug effects/metabolism/pathologyTight Junctions/drug effectsZonula Occludens-1 Protein/biosynthesis/drug effects/genetics
Identifiers
PMID: 24008412
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Research group Ophtalmologie expérimentale (925)
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TIEN, Thomas et al. Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells. In: Investigative Ophthalmology & Visual Science, 2013, vol. 54, n° 10, p. 6518-25. https://archive-ouverte.unige.ch/unige:90383

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Deposited on : 2016-12-15

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