Scientific article
English

Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells

Published inInvestigative ophthalmology & visual science, vol. 54, no. 10, p. 6518-6525
Publication date2013
Abstract

To investigate whether high glucose (HG)-induced downregulation of connexin 43 (Cx43), a gap junction protein, alters ZO-1 and occludin expression and cell monolayer permeability.

Keywords
  • Animals
  • Blotting
  • Western
  • Cell Communication/drug effects/genetics
  • Cells
  • Cultured
  • Connexin 43/biosynthesis/drug effects/genetics
  • Diabetes Mellitus
  • Experimental
  • Diabetic Retinopathy/genetics/metabolism/pathology
  • Down-Regulation/drug effects
  • Epithelial Cells/drug effects/metabolism/pathology
  • Glucose/pharmacology
  • Occludin/biosynthesis/drug effects/genetics
  • RNA
  • Messenger/genetics
  • Rats
  • Retina/drug effects/metabolism/pathology
  • Tight Junctions/drug effects
  • Zonula Occludens-1 Protein/biosynthesis/drug effects/genetics
Citation (ISO format)
TIEN, Thomas et al. Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells. In: Investigative ophthalmology & visual science, 2013, vol. 54, n° 10, p. 6518–6525. doi: 10.1167/iovs.13-11763
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0146-0404
458views
0downloads

Technical informations

Creation30/11/2016 09:35:00
First validation30/11/2016 09:35:00
Update15/03/2023 01:10:49
Status update15/03/2023 01:10:49
Last indexation31/10/2024 05:36:57
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack