Doctoral thesis

Impaired social functioning contributes to the pain of borderline personality disorder

ContributorsDoell, Kimberly
Defense date2016-11-03

Interpersonal dysfunction and self-injurious behaviors are core characteristics of borderline personality disorder (BPD) thus, the aim of this dissertation was to investigate the impaired neural processing of (negative) social signals in BPDs, and how this impairment affects the processing of physical pain. Using a combination of behavioral and neuroimaging techniques, the results from this dissertation add an important dimension to the understanding of the underlying neural mechanisms contributing to interpersonal dysfunction in BPD and show that these factors are strongly linked to early life stress. Specifically, the amygdala and temporal poles, key nodes of the social brain, were implicated in dysfunctional processing across these experiments further supporting impairments during emotional processing and an inability to properly integrate social signals by these patients. Additionally, these results help to clarify the mechanisms that may underlie the self-injury, a dangerous characteristic of this patient population.

  • Borderline personality disorder
  • Neuroimaging
  • Self-injurious behaviors
  • Childhood trauma
  • Reward
  • Punishment
  • The attachment system
  • Social exclusion
  • Physical pain
  • Social cognition
  • Social brain
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
Citation (ISO format)
DOELL, Kimberly. Impaired social functioning contributes to the pain of borderline personality disorder. 2016. doi: 10.13097/archive-ouverte/unige:90323
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Creation12/01/2016 10:57:00 AM
First validation12/01/2016 10:57:00 AM
Update time03/15/2023 1:10:09 AM
Status update03/15/2023 1:10:08 AM
Last indexation05/02/2024 6:02:11 PM
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