Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes

Daire, Jean-Luc; Leporq, Benjamin; Vilgrain, Valérie; Van Beers, Bernard E; Schmidt, Sabine; Pastor, Catherine

doi:10.1007/s13318-016-0382-x

Scientific article

English

Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes

Contributors

Daire, Jean-Luc; Leporq, Benjamin; Vilgrain, Valérie; Van Beers, Bernard E; Schmidt, Sabine; Pastor, Catherine

Published in

European journal of drug metabolism and pharmacokinetics, vol. 42, p. 657-667

Publication date

2017

Abstract

Gadobenate dimeglumine (Gd-BOPTA) is a commercialised hepatobiliary contrast agent used during liver magnetic resonance imaging (MRI) to detect liver diseases. It enters into human hepatocytes through organic anion transporting polypeptides (OATP1B1/B3) and crosses the canalicular transporter multiple resistance-associated protein 2 (MRP2) to be excreted into bile canaliculi. Gd-BOPTA can return to sinusoids via the sinusoidal transporters MRP3/MRP4. Hepatocyte concentrations of Gd-BOPTA depend on three clearances: the sinusoidal clearance or volume of sinusoidal blood cleared of drugs per unit of time and two hepatocyte clearances (into bile canaliculi or back to sinusoids) or volume of hepatocytes cleared of drugs per unit of time in the respective liver compartments. The present study investigates whether changing liver blood flow modifies hepatocyte concentrations when plasma concentrations do not change.

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

UNIGE research groups

Pharmacologie et imagerie du foie (664)

Citation (ISO format)

DAIRE, Jean-Luc et al. Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. In: European journal of drug metabolism and pharmacokinetics, 2017, vol. 42, p. 657–667. doi: 10.1007/s13318-016-0382-x

Article (Accepted version)

Identifiers

PID : unige:90294
DOI : 10.1007/s13318-016-0382-x
PMID : 27778300

Journal ISSN

0378-7966

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1downloads

Creation

25/11/2016 16:28:00

First validation

25/11/2016 16:28:00

Update

15/03/2023 01:09:50

Status update

15/03/2023 01:09:49

Last indexation

31/10/2024 05:35:00

Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation