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Title

Allelic mapping bias in RNA-sequencing is not a major confounder in eQTL studies

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Published in Genome Biology. 2014, vol. 15, no. 9, p. 467
Abstract RNA sequencing (RNA-seq) is the current gold-standard method to quantify gene expression for expression quantitative trait locus (eQTL) studies. However, a potential caveat in these studies is that RNA-seq reads carrying the non-reference allele of variant loci can have lower probability to map correctly to the reference genome, which could bias gene quantifications and cause false positive eQTL associations. In this study, we analyze the effect of this allelic mapping bias in eQTL discovery.
Keywords Chromosome MappingGenetic Association StudiesHuman Genome ProjectHumansPolymorphism, Single NucleotideQuantitative Trait LociSequence AlignmentSequence Analysis, RNA
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PMID: 25239376
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Article (Published version) (2 MB) - public document Free access
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Research group Population Genomics and Genetics of Complex Traits (892)
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PANOUSIS, Nikolaos et al. Allelic mapping bias in RNA-sequencing is not a major confounder in eQTL studies. In: Genome Biology, 2014, vol. 15, n° 9, p. 467. https://archive-ouverte.unige.ch/unige:90264

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Deposited on : 2016-12-13

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