Scientific article
English

P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies

Published inJournal of clinical epidemiology, vol. 68, no. 4, p. 460-465
Publication date2015
Abstract

In genome-wide association studies (GWASs), the practice regarding the choice of thresholds of significance and of thresholds used to include single nucleotide polymorphisms (SNPs) in a further validation stage is not well known. Here, we performed a systematic analysis of all GWASs published in two recent but nonconsecutive periods to assess whether any consensus was emerging regarding the choice of these thresholds.

Keywords
  • Data Interpretation, Statistical
  • Genome-Wide Association Study/methods
  • Humans
  • Polymorphism, Single Nucleotide
Citation (ISO format)
JANNOT BERTHIER, Anne-Sophie, EHRET, Georg Benedikt, PERNEGER, Thomas. P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies. In: Journal of clinical epidemiology, 2015, vol. 68, n° 4, p. 460–465. doi: 10.1016/j.jclinepi.2015.01.001
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0895-4356
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Technical informations

Creation09/11/2016 06:20:00
First validation09/11/2016 06:20:00
Update time24/01/2025 13:57:02
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