P &lt; 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies

Jannot Berthier, Anne-Sophie; Ehret, Georg Benedikt; Perneger, Thomas

doi:10.1016/j.jclinepi.2015.01.001

Scientific article

English

P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies

ContributorsJannot Berthier, Anne-Sophie; Ehret, Georg Benedikt; Perneger, Thomas

Published inJournal of clinical epidemiology, vol. 68, no. 4, p. 460-465

Publication date2015

Abstract

In genome-wide association studies (GWASs), the practice regarding the choice of thresholds of significance and of thresholds used to include single nucleotide polymorphisms (SNPs) in a further validation stage is not well known. Here, we performed a systematic analysis of all GWASs published in two recent but nonconsecutive periods to assess whether any consensus was emerging regarding the choice of these thresholds.

Keywords

Data Interpretation, Statistical
Genome-Wide Association Study/methods
Humans
Polymorphism, Single Nucleotide

Affiliation entities

Research groups

Citation (ISO format)

JANNOT BERTHIER, Anne-Sophie, EHRET, Georg Benedikt, PERNEGER, Thomas. P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies. In: Journal of clinical epidemiology, 2015, vol. 68, n° 4, p. 460–465. doi: 10.1016/j.jclinepi.2015.01.001

Article (Published version)

Identifiers

PID : unige:90162
DOI : 10.1016/j.jclinepi.2015.01.001
PMID : 25666886

Journal ISSN0895-4356

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First validation11/09/2016 6:20:00 AM

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P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies

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