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Title

P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies

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Published in Journal of Clinical Epidemiology. 2015, vol. 68, no. 4, p. 460-465
Abstract In genome-wide association studies (GWASs), the practice regarding the choice of thresholds of significance and of thresholds used to include single nucleotide polymorphisms (SNPs) in a further validation stage is not well known. Here, we performed a systematic analysis of all GWASs published in two recent but nonconsecutive periods to assess whether any consensus was emerging regarding the choice of these thresholds.
Keywords Data Interpretation, StatisticalGenome-Wide Association Study/methodsHumansPolymorphism, Single Nucleotide
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PMID: 25666886
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Research groups Traits génétiques complexes (901)
Epidémiologie clinique (115)
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JANNOT BERTHIER, Anne-Sophie, EHRET, Georg Benedikt, PERNEGER, Thomas. P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies. In: Journal of Clinical Epidemiology, 2015, vol. 68, n° 4, p. 460-465. https://archive-ouverte.unige.ch/unige:90162

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Deposited on : 2016-12-08

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