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Scientific article
Open access
English

Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study

Published inPloS one, vol. 9, no. 10, e109155
Publication date2014
Abstract

Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hypertension. Six genes--ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, and SH2B3--were evaluated for sequence variation with large effects on systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP).

Keywords
  • Aging/genetics
  • Blood Pressure/genetics
  • Cohort Studies
  • Heart/physiology
  • Humans
  • Sequence Analysis
Citation (ISO format)
MORRISON, Alanna C et al. Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. In: PloS one, 2014, vol. 9, n° 10, p. e109155. doi: 10.1371/journal.pone.0109155
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Article (Published version)
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ISSN of the journal1932-6203
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