Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study

Morrison, Alanna C; Bis, Joshua C; Hwang, Shih-Jen; Ehret, Georg Benedikt; Lumley, Thomas; Rice, Kenneth; Muzny, Donna; Gibbs, Richard A; Boerwinkle, Eric; Psaty, Bruce M; Chakravarti, Aravinda; Levy, Daniel

doi:10.1371/journal.pone.0109155

Scientific article

English

Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study

ContributorsMorrison, Alanna C; Bis, Joshua C; Hwang, Shih-Jen; Ehret, Georg Benedikt; Lumley, Thomas; Rice, Kenneth; Muzny, Donna; Gibbs, Richard A; Boerwinkle, Eric; Psaty, Bruce M; Chakravarti, Aravinda; Levy, Daniel

Published inPloS one, vol. 9, no. 10, e109155

Publication date2014

Abstract

Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hypertension. Six genes--ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, and SH2B3--were evaluated for sequence variation with large effects on systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP).

Keywords

Aging/genetics
Blood Pressure/genetics
Cohort Studies
Heart/physiology
Humans
Sequence Analysis

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Génétique (901)

Citation (ISO format)

MORRISON, Alanna C et al. Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. In: PloS one, 2014, vol. 9, n° 10, p. e109155. doi: 10.1371/journal.pone.0109155