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Title

TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens
Authors
Prados, Julien
Linder, Patrick
Redder, Peter
Published in BMC genomics. 2016, vol. 17, no. 1, 849
Abstract Bacteria rely on efficient gene regulatory mechanisms to switch between genetic programs when they are facing new environments. Although this regulation can occur at many different levels, one of the key steps is the initiation of transcription. Identification of the first nucleotide transcribed by the RNA polymerase is therefore essential to understand the underlying regulatory processes, since this provides insight on promoter strength and binding sites for transcriptional regulators, and additionally reveals the exact 5' untranslated region of the transcripts, which often contains elements that regulate translation.
Identifiers
PMID: 27806702
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Article (Published version) (1.5 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group Acquisition et expression de facteurs de virulence chez Staphylococcus aureus (86)
Citation
(ISO format) 		PRADOS, Julien, LINDER, Patrick, REDDER, Peter. TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens. In: BMC genomics, 2016, vol. 17, n° 1, p. 849. doi: 10.1186/s12864-016-3211-3 https://archive-ouverte.unige.ch/unige:90145

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Deposited on : 2016-12-08

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