en
Scientific article
English

Role of Vitamin D deficiency in extraskeletal complications: predictor of health outcome or marker of health status?

ContributorsGuessous, Idris
Published inBioMed research international, vol. 2015, 563403
Publication date2015
Abstract

The relationship of vitamin D with extraskeletal complications, such as cardiovascular disease, cancer, and autoimmune disease, is of major interest considering its roles in key biological processes and the worldwide high prevalence of vitamin D deficiency. However, the causal relationships between vitamin D and most extraskeletal complications are weak. Currently, a heated debate over vitamin D is being conducted according to two hypotheses. In this review, we first present the different arguments that suggest a major role of vitamin D in a very broad type of extraskeletal complications (hypothesis #1). We then present results from recent meta-analyses of randomized controlled trials indicating a lack of association of vitamin D with major extraskeletal complications (hypothesis #2). We discuss different issues (e.g., causality, confounding, reverse causation, misclassification, and Mendelian randomization) that contribute to the favoring of one hypothesis over the other. While ultimately only one hypothesis is correct, we anticipate that the results from the ongoing randomized controlled trials will be unlikely to reconcile the divided experts.

Keywords
  • Autoimmune Diseases/etiology/metabolism
  • Cardiovascular Diseases/etiology/metabolism
  • Humans
  • Vitamin D/metabolism
  • Vitamin D Deficiency/complications/metabolism
Citation (ISO format)
GUESSOUS, Idris. Role of Vitamin D deficiency in extraskeletal complications: predictor of health outcome or marker of health status? In: BioMed research international, 2015, vol. 2015, p. 563403. doi: 10.1155/2015/563403
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal2314-6133
382views
0downloads

Technical informations

Creation11/09/2016 3:02:00 PM
First validation11/09/2016 3:02:00 PM
Update time03/15/2023 1:07:28 AM
Status update03/15/2023 1:07:27 AM
Last indexation01/16/2024 10:39:56 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack