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Systemic allergic reaction and diffuse bone pain after exposure to a preparation of betamethasone

Published in European Journal of Internal Medicine. 2005, vol. 16, no. 8, p. 612-614
Abstract Allergic reactions to corticosteroids are unexpected as they seem to contradict their pharmacodynamic action. Nevertheless, they are not infrequent, with an estimated incidence of up to 4% for cutaneous reactions. Systemic reactions are rarely reported, but their incidence might be underestimated. We report here an unusual allergic reaction to betamethasone presenting with diffuse bone pain, erythema, and bronchoconstriction, which was confirmed by a positive rechallenge in a double-blind procedure. This is the first case report of a systemic reaction to betamethasone confirmed by a positive rechallenge. An impurity in betamethasone diproprionate cannot be excluded. As this substance is frequently used in rheumatologic soft-tissue injections, it is important to recognize this potentially life-threatening side effect.
PMID: 16314250
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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EHRET, Georg Benedikt et al. Systemic allergic reaction and diffuse bone pain after exposure to a preparation of betamethasone. In: European Journal of Internal Medicine, 2005, vol. 16, n° 8, p. 612-614. doi: 10.1016/j.ejim.2005.04.004 https://archive-ouverte.unige.ch/unige:90096

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Deposited on : 2016-12-08

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