en
Scientific article
French

Entre sel et gènes ou pharmacogénomique des antihypertenseurs

Published inRevue médicale suisse, vol. 2, no. 61, p. 986-991
Publication date2006
Abstract

Pharmacogenomics studies the links between polymorphisms (genetic variants) and the variability of the response to some treatments in a given individual. Pharmacogenomics thus allows to explore polymorphisms that could potentially explain heterogeneous efficacy of diuretics, ACE inhibitors or angiotensin receptor blockers, beta-blockers and calcium channel blockers among populations of varied ethnical origin. There have been many studies on the relation between the efficacy of these treatments and the specific polymorphisms involved in the regulation of blood pressure. So far, no unique mutation is by itself predictive of the therapeutic response to these drugs; more elaborated polygenetic models are required so that pharmacogenomics can one day offer an individualized prescription for a complicated disease such as high blood pressure.

Keywords
  • Antihypertensive Agents/pharmacology/therapeutic use
  • Blood Pressure/drug effects
  • Genomics
  • Humans
  • Hypertension/drug therapy/genetics/metabolism
  • Polymorphism, Genetic
  • Sodium/metabolism
Citation (ISO format)
ERNANDEZ, Thomas et al. Entre sel et gènes ou pharmacogénomique des antihypertenseurs. In: Revue médicale suisse, 2006, vol. 2, n° 61, p. 986–991.
Identifiers
ISSN of the journal1660-9379
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