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Scientific article
English

PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

Published inNature neuroscience, vol. 19, no. 3, p. 454-464
Publication date2016
Abstract

Long-term consolidation of memories depends on processes occurring many hours after acquisition. Whether this involves plasticity that is specifically required for long-term consolidation remains unclear. We found that learning-induced plasticity of local parvalbumin (PV) basket cells was specifically required for long-term, but not short/intermediate-term, memory consolidation in mice. PV plasticity, which involves changes in PV and GAD67 expression and connectivity onto PV neurons, was regulated by cAMP signaling in PV neurons. Following induction, PV plasticity depended on local D1/5 dopamine receptor signaling at 0-5 h to regulate its magnitude, and at 12-14 h for its continuance, ensuring memory consolidation. D1/5 dopamine receptor activation selectively induced DARPP-32 and ERK phosphorylation in PV neurons. At 12-14 h, PV plasticity was required for enhanced sharp-wave ripple densities and c-Fos expression in pyramidal neurons. Our results reveal general network mechanisms of long-term memory consolidation that requires plasticity of PV basket cells induced after acquisition and sustained subsequently through D1/5 receptor signaling.

Keywords
  • Animals
  • Cyclic AMP/physiology
  • Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism
  • Extracellular Signal-Regulated MAP Kinases/metabolism
  • Glutamate Decarboxylase/metabolism
  • Memory Consolidation
  • Memory, Long-Term/physiology
  • Memory, Short-Term/physiology
  • Mice
  • Neuronal Plasticity/physiology
  • Neurons/metabolism/physiology
  • Parvalbumins/metabolism
  • Receptors, Dopamine D1/physiology
  • Receptors, Dopamine D5/physiology
  • Signal Transduction
  • Time Factors
Citation (ISO format)
KARUNAKARAN, Smitha et al. PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation. In: Nature neuroscience, 2016, vol. 19, n° 3, p. 454–464. doi: 10.1038/nn.4231
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Article (Published version)
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ISSN of the journal1097-6256
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