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PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

Karunakaran, Smitha
Chowdhury, Ananya
Donato, Flavio
Caroni, Pico
Published in Nature Neuroscience. 2016, vol. 19, no. 3, p. 454-464
Abstract Long-term consolidation of memories depends on processes occurring many hours after acquisition. Whether this involves plasticity that is specifically required for long-term consolidation remains unclear. We found that learning-induced plasticity of local parvalbumin (PV) basket cells was specifically required for long-term, but not short/intermediate-term, memory consolidation in mice. PV plasticity, which involves changes in PV and GAD67 expression and connectivity onto PV neurons, was regulated by cAMP signaling in PV neurons. Following induction, PV plasticity depended on local D1/5 dopamine receptor signaling at 0-5 h to regulate its magnitude, and at 12-14 h for its continuance, ensuring memory consolidation. D1/5 dopamine receptor activation selectively induced DARPP-32 and ERK phosphorylation in PV neurons. At 12-14 h, PV plasticity was required for enhanced sharp-wave ripple densities and c-Fos expression in pyramidal neurons. Our results reveal general network mechanisms of long-term memory consolidation that requires plasticity of PV basket cells induced after acquisition and sustained subsequently through D1/5 receptor signaling.
Keywords AnimalsCyclic AMP/physiologyDopamine and cAMP-Regulated Phosphoprotein 32/metabolismExtracellular Signal-Regulated MAP Kinases/metabolismGlutamate Decarboxylase/metabolismMemory ConsolidationMemory, Long-Term/physiologyMemory, Short-Term/physiologyMiceNeuronal Plasticity/physiologyNeurons/metabolism/physiologyParvalbumins/metabolismReceptors, Dopamine D1/physiologyReceptors, Dopamine D5/physiologySignal TransductionTime Factors
PMID: 26807952
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Research group Organisation et plasticité des réseaux neuronaux cérébraux (148)
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KARUNAKARAN, Smitha et al. PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation. In: Nature Neuroscience, 2016, vol. 19, n° 3, p. 454-464. doi: 10.1038/nn.4231 https://archive-ouverte.unige.ch/unige:90059

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Deposited on : 2016-12-07

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