Article scientifique

Pathological gambling: update on decision making and neuro-functional studies in clinical samples

Publié dansCurrent pharmaceutical design, vol. 20, no. 25, p. 4000-4011
Date de publication2014

Given the importance and the burden of pathological gambling (PG) and its effect on gamblers and their relatives, better comprehension of the phenomena involved in its development and persistence is needed. The present paper describes the previous 5 years of studies on decision making and magnetic resonance imaging in people with PG. Twenty-six studies (456 participants with PG) were included. Perseveration in monetary tasks was associated with PG despite intact executive planning abilities. PG was linked with impairment in decision making under uncertainty. Hyperactivation of the reward pathway was repeatedly found. PG was also linked with neural hyperactivation of the reward pathway during high-risk conditions and hypoactivation in low-risk conditions. Furthermore, in PG, near misses activated the brain regions related to wins. Numerous similarities were found between PG and substance use disorders, highlighting the scientific basis of the recent reclassification of PG in the spectrum of addictive disorders.

  • Decision Making
  • Gambling/pathology/physiopathology/psychology
  • Humans
  • Magnetic Resonance Imaging
  • Neuropsychological Tests
  • Neurotic Disorders/pathology/physiopathology/psychology
Groupe de recherche
Citation (format ISO)
ACHAB, Sophia, KARILA, Laurent, KHAZAAL, Yasser. Pathological gambling: update on decision making and neuro-functional studies in clinical samples. In: Current pharmaceutical design, 2014, vol. 20, n° 25, p. 4000–4011.
ISSN du journal1381-6128

Informations techniques

Création24/10/2016 11:27:00
Première validation24/10/2016 11:27:00
Heure de mise à jour15/03/2023 01:06:15
Changement de statut15/03/2023 01:06:15
Dernière indexation02/05/2024 18:00:49
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