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A compressible scaffold for minimally invasive delivery of large intact neuronal networks

Peric, Oliver
Fantner, Georg E
Mosser, Sébastien
Fraering, Patrick C
Benchérif, Sidi
Mooney, David J
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Published in Advanced healthcare materials. 2015, vol. 4, no. 2, p. 301-12
Abstract Millimeter to centimeter-sized injectable neural scaffolds based on macroporous cryogels are presented. The polymer-scaffolds are made from alginate and carboxymethyl-cellulose by a novel simple one-pot cryosynthesis. They allow surgical sterility by means of autoclaving, and present native laminin as an attachment motive for neural adhesion and neurite development. They are designed to protect an extended, living neuronal network during compression to a small fraction of the original volume in order to enable minimally invasive delivery. The scaffolds behave as a mechanical meta-material: they are soft at the macroscopic scale, enabling injection through narrow-bore tubing and potentially good cellular scaffold integration in soft target tissues such as the brain. At the same time, the scaffold material has a high local Young modulus, allowing protection of the neuronal network during injection. Based on macroscopic and nanomechanical characterization, the generic geometrical and mechanical design rules are presented, enabling macroporous cellular scaffold injectability.
Keywords Alginates/pharmacologyCarboxymethylcellulose Sodium/pharmacologyCell Adhesion/drug effectsCell Line, TumorCell Survival/drug effectsComputer SimulationCryogels/pharmacologyDrug Delivery SystemsFinite Element AnalysisGlucuronic Acid/pharmacologyHexuronic Acids/pharmacologyHumansInjectionsNeurons/cytologyStress, MechanicalTissue Scaffolds/chemistry
PMID: 25178838
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Article (Accepted version) (4.1 MB) - public document Free access
Research groups LMIS4/EPFL
Groupe Thomas Braschler (970)
Swiss National Science Foundation: PBELP3-133350
Swiss National Science Foundation: IZK0Z2_154342
(ISO format)
BEDUER, Amélie et al. A compressible scaffold for minimally invasive delivery of large intact neuronal networks. In: Advanced healthcare materials, 2015, vol. 4, n° 2, p. 301-12. doi: 10.1002/adhm.201400250 https://archive-ouverte.unige.ch/unige:89963

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Deposited on : 2016-12-07

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