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Scientific article
English

Hepatocyte growth factor: A regulator of inflammation and autoimmunity

Published inAutoimmunity reviews, vol. 14, no. 4, p. 293-303
Publication date2015
Abstract

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.

Keywords
  • Animals
  • Autoimmunity
  • Hepatocyte Growth Factor/metabolism
  • Humans
  • Inflammation/immunology
  • Signal Transduction
Citation (ISO format)
MOLNARFI, Nicolas et al. Hepatocyte growth factor: A regulator of inflammation and autoimmunity. In: Autoimmunity reviews, 2015, vol. 14, n° 4, p. 293–303. doi: 10.1016/j.autrev.2014.11.013
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Article (Published version)
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ISSN of the journal1568-9972
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