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Scientific article
English

The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells

Published inJournal of neuroimmunology, vol. 267, no. 1-2, p. 105-110
Publication date2014
Abstract

Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS.

Keywords
  • Adult
  • Aged
  • Antigens, CD274/metabolism
  • Cytokines/metabolism
  • Dendritic Cells/drug effects
  • Female
  • Flow Cytometry
  • HLA-DR Antigens/metabolism
  • Hepatocyte Growth Factor/pharmacology
  • Humans
  • Male
  • Middle Aged
  • Monocytes/cytology/drug effects
  • T-Lymphocytes/drug effects
  • Young Adult
Citation (ISO format)
MOLNARFI, Nicolas et al. The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells. In: Journal of neuroimmunology, 2014, vol. 267, n° 1-2, p. 105–110. doi: 10.1016/j.jneuroim.2013.12.004
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Article (Published version)
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Identifiers
ISSN of the journal0165-5728
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