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The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells

Published in Journal of Neuroimmunology. 2014, vol. 267, no. 1-2, p. 105-110
Abstract Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS.
Keywords AdultAgedAntigens, CD274/metabolismCytokines/metabolismDendritic Cells/drug effectsFemaleFlow CytometryHLA-DR Antigens/metabolismHepatocyte Growth Factor/pharmacologyHumansMaleMiddle AgedMonocytes/cytology/drug effectsT-Lymphocytes/drug effectsYoung Adult
PMID: 24367900
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Research group Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
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MOLNARFI, Nicolas et al. The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells. In: Journal of Neuroimmunology, 2014, vol. 267, n° 1-2, p. 105-110. https://archive-ouverte.unige.ch/unige:89940

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Deposited on : 2016-12-07

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