en
Scientific article
English

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

Published inLancet, vol. 387, no. 10023, p. 1085-1093
Publication date2016
Abstract

Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.

Keywords
  • Bipolar Disorder/drug therapy/genetics
  • Female
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics
  • Humans
  • Lithium Compounds/therapeutic use
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide/genetics
  • Prospective Studies
  • Treatment Outcome
Citation (ISO format)
HOU, Liping et al. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. In: Lancet, 2016, vol. 387, n° 10023, p. 1085–1093. doi: 10.1016/S0140-6736(16)00143-4
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Article (Published version)
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Identifiers
ISSN of the journal0140-6736
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Technical informations

Creation10/07/2016 12:31:00 PM
First validation10/07/2016 12:31:00 PM
Update time03/15/2023 1:05:32 AM
Status update03/15/2023 1:05:31 AM
Last indexation01/16/2024 10:35:39 PM
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