Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

Hou, Liping; Heilbronner, Urs; Degenhardt, Franziska; Kelsoe, John R; Alda, Martin; Rietschel, Marcella; McMahon, Francis J; Schulze, Thomas G

doi:10.1016/S0140-6736(16)00143-4

Scientific article

English

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

ContributorsHou, Liping; Heilbronner, Urs; Degenhardt, Franziska; Kelsoe, John R; Alda, Martin; Rietschel, Marcella; McMahon, Francis J; Schulze, Thomas G

CollaboratorsDayer, Alexandre; Aubry, Jean-Michel

Published inLancet, vol. 387, no. 10023, p. 1085-1093

Publication date2016

Abstract

Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.

Keywords

Bipolar Disorder/drug therapy/genetics
Female
Genetic Variation
Genome-Wide Association Study
Genotype
Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics
Humans
Lithium Compounds/therapeutic use
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide/genetics
Prospective Studies
Treatment Outcome

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Citation (ISO format)

HOU, Liping et al. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. In: Lancet, 2016, vol. 387, n° 10023, p. 1085–1093. doi: 10.1016/S0140-6736(16)00143-4

Article (Published version)

Identifiers

PID : unige:89914
DOI : 10.1016/S0140-6736(16)00143-4
PMID : 26806518

Journal ISSN0140-6736

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Creation07/10/2016 14:31:00

First validation07/10/2016 14:31:00

Update time15/03/2023 02:05:32

Status update15/03/2023 02:05:31

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Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.

Technical informations